ABSTRACT
The present report describes a case of onychoprotothecosis caused by Prototheca wickerhamii in a nonimmunocompromized female. Dermatological examination showed yellowish discoloration of the left and right forefinger nails, showing onicolysis and hyperkeratosis. The repeated isolation of the algae Prototheca (organisms morula-like) as well as the repeated culture in media, Sabouraud agar, confirmed the diagnosis. The patient was successfully treated with tioconazol 1% topic solution. The aim of this paper was to present a rare condition.
Subject(s)
Infections/diagnosis , Nail Diseases/diagnosis , Prototheca/growth & development , Brazil , Female , Humans , Imidazoles/therapeutic use , Infections/drug therapy , Infections/microbiology , Middle Aged , Nail Diseases/drug therapy , Nail Diseases/microbiology , Prototheca/drug effects , Prototheca/isolation & purification , Treatment OutcomeABSTRACT
The present report describes a case of cutaneous protothecosis caused by Prototheca wickerhamii in a nonimmunocompromised Brazilian female. Dermatological examination revealed a 15-cm diffusely infiltrated eczema-like plaque recovered with many pustule-like lesions on the right forearm. We emphasize the mycological and pathological aspects of this infection that can lead to misdiagnosis. The patient was successfully treated with itraconazole.
Subject(s)
Infections/diagnosis , Prototheca/isolation & purification , Skin Diseases, Infectious/diagnosis , Aged , Antifungal Agents/therapeutic use , Female , Forearm , Humans , Immunocompetence , Infections/drug therapy , Itraconazole/therapeutic use , Skin Diseases, Infectious/drug therapyABSTRACT
The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes.
Subject(s)
Cryptococcosis/microbiology , Dermatomycoses/microbiology , Aged , Cryptococcus neoformans/isolation & purification , Humans , Immunocompromised Host , MaleABSTRACT
The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes
Subject(s)
Humans , Male , Aged , Cryptococcosis , Dermatomycoses , Cryptococcus neoformans , Immunocompromised HostSubject(s)
Acquired Immunodeficiency Syndrome/complications , Mycoses/complications , Trichoderma , Humans , Male , Middle AgedABSTRACT
We report a case of cutaneous infection caused by Phialemonium curvatum GAMS et COOKE, 1983, after bone marrow transplantation. The genus Phialemonium was created by GAMS & MCGINNIS in 1983 including three new species: Ph. obovatum, Ph. curvatum and Ph. dimorphosporum, and represents an intermediate genus between Acremonium and Phialophora. Nowadays, the genus Phialemonium is considered to be a pheoid fungus which may cause the eventual lesions observed in pheo- and hyalohyphomycosis. Species of this genus have been described as opportunistic agents in humans and animals, mainly as a result of immunosuppression. In the present case, the patient had multiple myeloma and received an allogenic bone marrow transplant from his HLA-compatible brother. Two months after transplantation, he developed purplish and painful nodular lesions on the right ankle. Some of these lesions drained spontaneously and apparently hyaline mycelial filaments were observed, whose culture was initially identified as Acremonium sp. Subsequent studies showed that the fungus was Phialemonium curvatum. The infection was treated with amphotericin B, followed by ketoconazole. The patient was submitted to surgical debridement followed by two skin grafts to repair the bloody area. The duration of the treatment was 4 months and secondary prophylaxis with ketoconazole alone was maintained for one additional month. No recurrence was observed after discontinuation of treatment. The authors comment on the pathogenicity of the genus Phialemonium
Subject(s)
Humans , Male , Adult , Bone Marrow Transplantation/adverse effects , Dermatomycoses/microbiology , Mitosporic Fungi/isolation & purification , Opportunistic Infections/complications , Dermatomycoses/drug therapyABSTRACT
Os autores registram um caso de eumicetoma de gräos branco-amarelados, em paciente do sexo masculino, procedente da Bahia, com lesöes no pé esquerdo, provocadas por Acremonium kiliense (Grütz, 1925). O exame histopatológico näo demonstrou a presença de gräos, revelados, todavia, ao exame "a fresco", todos eles com estrutura de eumicetos. Discreta regressäo do quadro inflamatório com o uso de itraconazol, após tratamento prolongado
Subject(s)
Humans , Male , Middle Aged , Acremonium , Foot Dermatoses , Itraconazole/therapeutic use , MycetomaABSTRACT
The authors report the first case of dermatophytosis caused by Trichophyton raubitschekii in a patient from the State of São Paulo with Tinea corporis lesions localized on the buttocks. Culture on Sabouraud-agar with cycloheximide permitted the isolation and identification of the fungus, and the diagnosis was confirmed by Dr. Lynne Sigler, University of Alberta, Canada. Systemic treatment with fluconazole, 150 mg/week for 4 weeks, in combination with topical treatment with isoconazole initially yielded favorable results, with recurrence of the lesions after the medication was discontinued. This is the fifth case of this dermatophytosis published in the Brazilian medical literature
Subject(s)
Humans , Female , Tinea/microbiology , Trichophyton/isolation & purification , Antifungal Agents/therapeutic use , Fluconazole/therapeutic use , Tinea/diagnosis , Tinea/drug therapyABSTRACT
The authors report two cases of onychomycosis in the dystrophic form, one of them involving an HIV-positive patient, provoked by Scytalidium dimidiatum, previously called Scytalidium lignicola. The subject is reviewed from the taxonomic viewpoint, considering the anamorph Hendersonula toruloidea as a synonym of Nattrassia mangiferae, and having Scytalidium dimidiatum as the major synanamorph. According to many mycologists, Scytalidium hyalinum may be a separate species or a hyaline mutant of Scytalidium dimidiatum. Scytalidium lignicola Pesante 1957 was considered to be the type-species of the genus by ELLIS (1971)13 and later to be a "conidial state" of Hendersonula toruloidea by the same author, today known as Nattrassia mangiferae. The microorganism lives only on the roots of certain plants (mainly Platanus and Pinus). It produces pycnidia and is not considered to be a pathogen, although it is considered as a possible emerging agent capable of provoking opportunistic fungal lesions. The importance of this topic as one of the most outstanding in fungal taxonomy, so likely to be modified over time, as well as its interest in the field of dermatologic mycology, are emphasized
Subject(s)
Humans , Male , Adult , Female , Mitosporic Fungi/classification , Onychomycosis/microbiology , Antifungal Agents/therapeutic use , Foot Dermatoses/drug therapy , Foot Dermatoses/microbiology , Hand Dermatoses/drug therapy , Hand Dermatoses/microbiology , Itraconazole/therapeutic use , Ketoconazole/therapeutic use , Mitosporic Fungi/isolation & purification , Onychomycosis/drug therapyABSTRACT
O presente trabalho registra caso de histoplasmose em paciente de 5 anos, HIV negativo, natural e procedente da cidade da Sao Paulo, com lesoes cutaneas nao diagnosticadas clinicamente. Exame histopatologico negativo para infeccao fungica. Cultivos em duas ocasioes, positivos para Histoplasma capsulatum var. capsulatum (amostras 361 e 387). Sorologia negativa para anticorpos anti-Histoplasma capsulatum e Paracoccidioides brasiliensis pelas provas de Imunodifusao dupla e ...
Subject(s)
Humans , Child , Erythema Infectiosum/etiology , Histoplasma/isolation & purification , Histoplasmosis/diagnosis , Atypical Bacterial Forms , Blotting, Western , Culture Media , Fever , Fever/etiology , Histoplasmosis/immunology , Histoplasmosis/therapy , Immunocompromised Host/immunology , Immunohistochemistry , Itraconazole/therapeutic use , Polysaccharides, Bacterial/analysisABSTRACT
Os autores estudaram do ponto de vista micologico, imunoquimico e de sua biologia molecular, duas amostras de Paracoccidioides brasiliensis, uma isolada do solo, no municipio de IBIA (MG) por Silva-Vergara et al (1996,1998) denominada IBIA e outra, BAT, cultivada de um caso humano de paracoccidioidomicose em Ribeirao Preto (SP) por Freitas da Silva (1996). Tais amostras apresentam colonias cotonosa (M) e leveduriforme (L ou Y), sendo patogenicas para cobaios inoculados por via testicular, produzindo orquite granulomatosa e/ou supurativa. Do ponto de vista imunoquimico, atraves de provas de Imunodifusao dupla, Imunoeletroforese e Western Blotting, foi demostrada a presenca da gp43
Subject(s)
Humans , Animals , Immunochemistry/methods , Mycology , Paracoccidioidomycosis/immunology , Base Sequence , Blotting, Western , Immunodiffusion , Immunoelectrophoresis , Orchitis/pathology , Paracoccidioides/isolation & purificationABSTRACT
Coccidioidomicose e infecçäo endemica com distribuiçäo geográfica relativamente limitada: Mexico, Guatemala, Honduras, Colombia, Venezuela, Bolivia, Paraguai, Argentina e Sudeste dos Estados Unidos. Nestes paises, a area endemica esta restrita a regiöes deserticas ou semiaridas, semelhantes as do Nordeste do Brasil. Registro do caso: paciente masculino de 32 anos, nascido no Estado da Bahia (Nordeste do Estado), vivendo ha seis anos em Säo Paulo (Sudeste). Foi admitido no Departamento de Pneumologia do Hospital das Clínicas em outubro de 1996, com historia de tosse produtiva e progressiva ha seis meses, febre, mal estar, calafrios, perda de peso, fraqueza e artralgia das pequenas articulaçöes...
Subject(s)
Humans , Male , Adult , Coccidioides/isolation & purification , Coccidioidomycosis/diagnosis , Lung Diseases, Fungal/diagnosis , Immunodiffusion , Radiography, Thoracic/methods , Tomography, X-Ray ComputedABSTRACT
O presente trabalho registra um caso de feo-hifomicose subcutanea em paciente do sexo masculino com o diagnostico de sarcoidose pulmonar, submetido a terapeutica por corticosteroides quando apresentou no dorso da mao direita lesoes cutaneas nodulares, eritemato-violaceas, de aspecto infiltrado, exigindo biopsia para o diagnostico. O exame histopatologico revelou processo granulomatoso, com a presenca de hifas e celulas arredondadas demacias...
Subject(s)
Humans , Middle Aged , Male , Sarcoidosis/diagnosis , Skin/injuries , Adrenal Cortex Hormones/therapeutic use , Anti-Bacterial Agents/therapeutic use , Biopsy , Sarcoidosis/therapyABSTRACT
As basidiomicoses, infeccoes fungicas provocadas por basidiomicetos vem sendo registradas cada vez com maior frequencia na literatura medica, principalmente apos o advento da AIDS/SIDA, em 1981. Os basidiosporos desses fungos, espalhados na atmosfera e veiculados atraves do vento ou de correntes aereas, atingem por via nasal os seios maxilares, provocando quadros de sinusite cronica, na maioria das vezes. Do escarro tambem tem sido isolados basidiomicetos, principalmente o Schizophyllum commune. Lesoes da mucosa da boca, abscessos cerebrais, onicomicoses e endocardites ja foram descritas, aumentando o interesse dos micologistas e infectologistas para este tipo de micose profunda. O presente trabalho assinala, ao lado dos quadros de micetismo, processos infecciosos provocados por basidiomicetos, a exemplo do Schizophyllum commune, Ustilago maydis (=Ustilago zeae) e Coprinus cinereus
Subject(s)
Animals , Basidiomycota/classification , Mycoses/diagnosis , Schizophyllum/isolation & purificationABSTRACT
Os autores registram caso de hialo-hifomicose subcutanea por Acremonium recifei em paciente branca, imunocompetente, natural da Bahia, com historia de traumatismo no dorso da mao direita. A lesao era indolor, com edema, inflamacao, presenca de fistulas, secrecao seropulenta, e ausencia de graos. O exame histopatologico mostrou hifas septadas hialinas pela hematoxilina-eosina...
Subject(s)
Humans , Female , Aged , Acremonium/classification , Antifungal Agents/therapeutic use , Dermatomycoses/therapy , Dermatomycoses/diagnosisABSTRACT
Amostra de Paracoccidioides brasiliensis isolada de visceras (baco e figado) de um tatu (Dasipus novencintus)foi estudada no ponto de vista micologico e imunoquimico. O tatu havia sido capturado em area da usina hidroeletrica de Tucurui (Estado do Para). Este ja havia sido considerado como reservatorio enzootico do Paracoccidioides brasiliensis naquela regiao. Esta amostra, conservada na Micoteca do Instituto de Medicina Tropical de Sao Paulo sob o numero 135, apresenta todas as caracteristicas de Paracoccidioides brasiliensis, com elevado poder antigenico e baixa virulencia para cobaios e ratos Wistar. A demonstracao do exo-antigeno especifico do P. brasiliensis, representado pela glicoproteina de peso molecular 43 KDa, foi evidente atraves das tecnicas de Imunodifusao Dupla, Imunoeletroforese, SDS-PAGE e Imunoblotting.
Subject(s)
Animals , Cricetinae , Rabbits , Rats , Paracoccidioides/isolation & purification , Paracoccidioidomycosis/immunology , Armadillos/classification , Immunohistochemistry , Paracoccidioides/classificationABSTRACT
No presente trabalho sao registrados dois casos de aspergilose em criancas imunocomprometidas. O estudo micologico completo identificou Aspergillus flavus como agente de dois processos. A presenca cada vez mais frequente da aspergilose invasiva deve-se ao numero crescente de pacientes imunocomprometidos, muitos com hemopatias graves submetidos a quimioterapia. O diagnostico precoce em um dos casos possibilitou remissao do processo. Tratava-se de paciente com leucemia mieloide aguda, tendo sido isolado o fungo do sangue circulante. O segundo caso evoluiu para obito, com infeccao fungica generalizada.
